Kohekohe is a secondary ingredient in numerous treatment of kohepopo and associated problems. For example, it is used in conjunction with ‘alaea clay, noni (Morinda citrifolia), niu (coconut, Cocos nucifera), ‘ala‘alawainui pehu (Peperomia spp.), lehua (Metrosideros spp.), ‘ōhi‘a ‘ai (Syzygium malaccense), kukui (Aleurites moluccana), and kō‘aina kea (sugar cane, Saccharum officinarum) (Chun 1994:40). It is also a secondary ingredient in the preparation of medicine for nae, hoki‘i (tuberculosis), and hopoli, used with ‘ōkahakaha (fern), ‘uhaloa (Waltheria indica), noni, and kōkea (white sugarcane) (Chun 1994:69). Secondary ingredient in treatment of women who have had numerous children and red/bumpy skin on the face; it is combined with hala (Pandanus tectorius), pohepohe (Hydrocotyle verticillata), ‘ala‘alawainui pehu, ‘ihi makole (Oxalis corniculata), naio (Myoporum sandwicense), niu, kukui, noni, and kōkea (white sugarcane) or kōhonua‘ula (red sugarcane) (Chun 194:73–74). Kohekohe is also a secondary component of medicine to treat kohepopo along with ilioha (Conyza),‘ala‘alawainui pehu, ‘ōhi‘a ‘ai, leko (Nasturtium microphyllum), ‘aka‘akai ‘oliana (?), noni, and kōkea (Chun 1994:114–115). Secondary ingredient in the treatment of paia and kumulena (associated with kohepopo), along with ‘iwa (Asplenium horridum), ‘uwi‘uwi (ilioha, Conyza spp.), ‘ala‘alawainui pehu, ‘ōhi‘a ‘ai, noni, and kōhonua‘ula (Chun 1994:123). For illnesses, such as ke‘a, kahaea, papaku, nae‘oiku, wai‘opua, hopilo, and ni‘au (classified as kohepopo), kohekohe is a secondary ingedient with kukui, ‘ōhi‘a ‘ai, koa (Acacia koa), ‘ala‘alawainui pehu, ko‘oko‘olau (Bidens spp.), noni, ‘uhaloa (Waltheria indica), pōpolo (Solanum americanum), and kōkea (Chun 1994:171). For hoki‘i and ni‘au (forms of kohepopo), kohekohe is used as a secondary ingredient with mai‘a (banana, Musa spp.), ‘uhaloa, puakala (Argemone glauca), ‘ōhi‘a ‘ai, kukui, pōpolo, and kōkea (Chun 1994:206).